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Povidone-iodine and chlorhexidine are equally effective, and can be used interchangeably.

 

False

 

Traditional iodophors can take 2-3 minutes until the free release of iodine can occur. While the iodophor dries, free iodine becomes available. The iodine denatures the bacterial cell through the oxidation of two sulfhydryl groups, resulting in the formation of a disulfide bond. As a result, iodine products must be allowed to dry completely. The bactericidal effects last only ≤3 hours.(1) In addition, iodophors are neutralized in the presence of blood and organic matter.(2)

 

One of the advantages of chlorhexidine-based products is that they provide persistent antimicrobial activity (up to 48 hours) and effectiveness in the presence of blood and organic matter. Chlorhexidine gluconate, a cationic bisbiguanide, works by destroying the bacterial cell membrane and precipitating cell contents. When combined with isopropyl alcohol, chlorhexidine products also provide rapid bactericidal activity.(1)

 

REFERENCES:

(1) Crosby C, .Mares AK. Skin Antisepsis: Past, Present and Future. Journal of Vascular Access Devices. Spring 2001.1-6, 26-31.

 

(2) Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine Compared with Povidone-Iodine Solution for Vascular Site Care: A Meta-Analysis. Annals of Internal Medicine. June 2002. Volume 136 Number 11. Page 792-801.

 

 

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